In a tweet written on the anniversary of the upheaval that was also sent out in Farsi, Trump said: "40 years of corruption. 40 years of repression. 40 years of terror. The regime in Iran has produced only #40YearsofFailure.
"The long-suffering Iranian people deserve a much brighter future," he added.
Earlier, Trump's chief foreign policy advisor John Bolton issued a similar statement, tweeting that "it's been 40 yrs of failure. Now it's up to the Iranian regime to change its behavior, & ultimately up to the Iranian people to determine the direction of their country."
Bolton said Washington would support "the will of the Iranian people, & stand behind them to ensure their voices are heard."
Bolton, a leading hawk in the Trump administration's attempt to weaken Iranian influence, was tweeting as a huge crowd in Tehran gathered to celebrate the 1979 revolution, in which Muslim leader Ayatollah Ruholla Khomeini ended the centuries-old rule of the royal dynasty.
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