The remarks underscore growing tension between the world's top two economies after the United States accused China of backing a string of hacking attacks on US companies and government agencies.
China says the accusation lacks proof and that it is also a victim of hacking attacks, more than half of which originate from the United States.
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The United States imports about $129 billion worth of "advanced technology products" from China, according to a May 2012 report by the US Congressional Research Service.
State media including Xinhua, the China Daily and the People's Daily, quoted a spokesman for the Ministry of Commerce as saying the US bill "sends a very wrong signal".
"This will directly impact partnerships of Chinese enterprises and American business as they conduct regular trade," said Shen Danyang, the commerce ministry spokesman.
"This abuse of so-called national security measures is unfair to Chinese enterprises, and extends the discriminatory practice of presumption of guilt," the article in the official People's Daily said, quoting Shen. "This severely damages mutual trust between the US and China."
The United States should eliminate the law, Shen said.
Technology security lawyer Stewart Baker wrote in a blog post this week that China could claim that the United States is violating World Trade Organization rules.
However, because Beijing hasn't signed a WTO agreement setting international rules for government procurement, it may not be successful in its challenge, Baker said.
Chinese foreign ministry spokesman Hong Lei also urged the US to abandon the law at a news conference on Thursday.
"This bill uses Internet security as an excuse to take discriminatory steps against Chinese companies," he said.
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