With the Obama administration taking fire at home and abroad for what is perceived to be its indecisive Syria policy and Arab unease about its outreach to Iran, Kerry is hitting the road again seeking to ease tensions and soothe allies vital to its Middle East ambitions.
After less than two weeks at home, the top US diplomat can expect some tough behind-the-scenes talks on his seven-nation tour, which will include a stop in the West Bank as well.
The November 3 to 11 trip will take in Saudi Arabia, Poland, Israel, Bethlehem, Amman, Abu Dhabi, Algeria and Morocco. First stop will be Riyadh for talks on Sunday with King Abdullah amid tensions with the Gulf Kingdom.
Kerry met earlier this month with Saudi Foreign Minister Saud al-Faisal in Paris when they discussed when "would be a good time for the secretary to come visit and talk about all the issues we work together on," State Department spokeswoman Jen Psaki said.
In Riyadh he would "reaffirm the strategic nature of the US-Saudi relationship," she added.
Ties have strained in recent months with Saudi Arabia over Washington's policy on the conflict in Syria and moves for a rapprochement with Riyadh's arch-foe Iran to rein in its suspect nuclear programme.
In an unprecedented move, Riyadh earlier this month turned down a coveted non-permanent seat on the UN Security Council in protest at the world body's failure to end the 31-month war in Syria which has left over 115,000 dead.
Saudi intelligence chief Prince Bandar Bin Sultan al-Saud reportedly told diplomats in Riyadh last week that he would scale back Saudi cooperation with the CIA on training Syrian rebels, and work with other allies including Jordan and France.
But Psaki stressed that Saudi Arabia is "an enormously important partner on issues like Syria and it's important to the secretary that as we look to see if there's a path forward with diplomacy in Iran, that we have that conversation with them."
Kerry, along with his Russian counterpart Sergei Lavrov, has been working for months to try to convene peace talks in Geneva slated for November, aimed at bringing together the Syrian regime and the opposition to chart a path to a transition of power.
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