Exposure to general anaesthesia boosts dementia risk in elderly by 35 pc

Elderly who have been exposed to general anaesthesia are at 35 percent more risk of suffering from dementia, a new research has claimed.

Postoperative cognitive dysfunction, or POCD, could be associated with dementia several years later.

POCD is a common complication in elderly patients after major surgery. It has been proposed that there is an association between POCD and the development of dementia due to a common pathological mechanism through the amyloid beta peptide.

Several experimental studies suggest that some anaesthetics could promote inflammation of neural tissues leading to POCD and/or Alzheimer's disease (AD) precursors including beta-amyloid plaques and neurofibrillary tangles. But it remains uncertain whether POCD can be a precursor of dementia.

In this new study, the researchers analysed the risk of dementia associated with anaesthesia within a prospective population-based cohort of elderly patients (aged 65 years and over).

The team used data from the Three-City study, designed to assess the risk of dementia and cognitive decline due to vascular risk factors. Between 1999 and 2001, the 3C study included 9294 community-dwelling French people aged 65 years and over in three French cities (Bordeaux, Dijon and Montpellier).

Participants aged 65 years and over were interviewed at baseline and subsequently 2, 4, 7 and 10 years after.

Each examination included a complete cognitive evaluation with systematic screening of dementia. From the 2-year follow-up, 7008 non-demented participants were asked at each follow-up whether they have had a history of anaesthesia (general anaesthesia (GA) or local/locoregional anaesthesia (LRA)) since the last follow-up.

The data were adjusted to take account of potential confounders such as socioeconomic status and comorbidities.

The mean age of participants was 75 years and 62 percent were women. At the 2-year follow-up, 33 percent of the participants (n=2309) reported an anaesthesia over the 2 previous years, with 19 percent (n=1333) reporting a GA and 14 percent (n=948) a LRA. A total of 632 (9 percent) participants developed dementia over the 8 subsequent years of follow-up, among them 284 probable AD and 228 possible AD, and the remaining 120 non-Alzheimer's dementia.

The researchers found that patients suffering from dementia were more likely to have received anaesthesia (37 percent) than patients who are not suffering from dementia (32 percent).

This difference in anaesthesia was due to difference in numbers receiving general anaesthetics, with 22 percent of patients reporting a GA compared with 19 percent of patients who were not suffering from dementia.

After adjustment, participants with at least one GA over the follow-up had a 35 percent increased risk of developing a dementia compared with participants without anaesthesia.