The locomotive driver apparently overshot the signal and as a result, the engine and two adjoining coaches derailed, Railway Spokesperson Anil Saxena said in Delhi.
The accident occurred around 9.30 AM near Bachhrawan Railway station, about 50 km from state capital, Lucknow.
"So far, 22 persons have died. There could be more casualties in the mishap," Divisional Commissioner, Lucknow, Mahesh Gupta told PTI.
Railways have ordered an inquiry and announced a compensation of Rs 2 lakh for the next of kin of those killed in the accident. While Rs 50,000 will be given to those injured seriously, Rs 20,000 will be given to people with minor injuries.
Yadav said that officers have been directed to provide all the possible help to the injured
Railway Minister Suresh Prabhu has instructed Chairman Railway Board A K Mittal and Member Traffic Ajay Shukla to rush to the spot.
As soon as the news of the accident spread, people from nearby villages rushed to the spot to help in rescue and relief operations.
The villagers helped in extricating passengers trapped in the mangled coaches of the train.
Ambulances carrying teams of doctors were rushed to the accident site to help passengers screaming in pain, eye witnesses said, adding gas cutters were being arranged to cut open the crushed compartments to pull out passengers.
Train movement on the Lucknow-Varanasi section of the Northern Railway has been disrupted due to the accident.
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