Villagers at the disaster site in Badakhshan province used shovels to dig through rocks and dirt, with local authorities, the United Nations and the NATO military force all racing to assess the damage and provide help.
"Two successive landslides within one hour hit Aab Bareek village today," Gul Mohammad Baidaar, deputy governor of Badakhshan, told AFP.
"A hill collapsed on the village. Most of those missing had gathered in two mosques to offer Friday prayers. The second landslide hit locals who came to help."
"Our initial findings based on local people's reports show around 2,500 people including women and children might be dead," he said.
"It is difficult to get confirmed information from the scene and we are seeking to determine the facts."
Badakhshan is a remote, mountainous province in northeast Afghanistan bordering Tajikistan, China and Pakistan.
It has been relatively peaceful since the US-led military intervention began in 2001, but has seen increasing Taliban activity in recent years,
"The number of deceased has increased to 350," the UN mission in Afghanistan said in a statement.
"(NATO's) Regional Command in the north (is) in contact with the Afghan National Army in regards to search and rescue efforts."
President Hamid Karzai said immediate action was being taken, with rescuing survivors the priority for emergency efforts, which continued as darkness fell.
Local officials said that the landslides occurred at about midday (1300 IST) in the Argo district after days of heavy rain.
Between 350 and 400 houses were destroyed, they said.
"It is a disaster. The landslide has affected around 1,000 families," Sayed Abdullah Homayun Dehqan, provincial director of the Afghan National Disaster Management Authority, told AFP.
"Around 700 families were rescued, we have sent in some basic assistance such as tents and blankets.
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