In an exclusive interview with AFP from his office in Damascus yesterday, Assad said he supported peace talks, but that negotiations do "not mean that we stop fighting terrorism".
He said a major Russian-backed government offensive under way in the northern province of Aleppo was aimed mainly at severing the opposition's supply route from Turkey.
Assad said he saw a risk that Turkey and Saudi Arabia, key backers of the opposition, would intervene militarily in Syria.
Assad rejected UN allegations of regime war crimes, describing them as "politicised" and lacking evidence.
With air support from key ally Russia and backing by pro-government fighters, regime troops have nearly encircled Aleppo, Syria's second city.
Assad said his regime's eventual goal was to retake all of Syria, large swathes of which are under the control of rebel forces or the Islamic State jihadist group.
"Regardless of whether we can do that or not, this is a goal we are seeking to achieve without any hesitation," he said.
Assad said it would be possible to "put an end to this problem in less than a year" if opposition supply routes from Turkey, Jordan and Iraq were cut.
But, if not, he said, "the solution will take a long time and will incur a heavy price."
The interview with Assad is the first he has given since the effective collapse of a new round of peace talks in Geneva earlier this month.
The talks are officially "paused" until February 25, and 17 nations agreed early today on an ambitious plan intended to bolster efforts for new negotiations.
Assad said his government has "fully believed in negotiations and in political action since the beginning of the crisis."
"However, if we negotiate, it does not mean that we stop fighting terrorism. The two tracks are inevitable in Syria."
The Aleppo offensive has been the main focus of Syrian government troops in recent weeks.
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