Brain structure may determine pain sensitivity

Your grey matter really does matter! Brain structure is linked to how intensely someone perceives pain, according to a new study.
Scientists at Wake Forest Baptist Medical Center investigated the relationship between the amount of grey matter and individual differences in pain sensitivity in 116 healthy volunteers.
"We found that individual differences in the amount of grey matter in certain regions of the brain are related to how sensitive different people are to pain," said Robert Coghill, professor of neurobiology and anatomy at Wake Forest Baptist and senior author of the study.
In the study, pain sensitivity was tested by having participants rate the intensity of their pain when a small spot of skin on their arm or leg was heated to 48.8 degrees Celsius.

After pain sensitivity testing, participants underwent MRI scans that recorded images of their brain structure.
"Subjects with higher pain intensity ratings had less grey matter in brain regions that contribute to internal thoughts and control of attention," said Nichole Emerson, a graduate student in the Coghill lab and first author of the study.

These regions include the posterior cingulate cortex, precuneus and areas of the posterior parietal cortex, she said.
The posterior cingulate cortex and precuneus are part of the default mode network, a set of connected brain regions that are associated with the free-flowing thoughts that people have while they are daydreaming.

"Default mode activity may compete with brain activity that generates an experience of pain, such that individuals with high default mode activity would have reduced sensitivity to pain," Coghill said.
Areas of the posterior parietal cortex play an important role in attention. Individuals who can best keep their attention focused may also be best at keeping pain under control, Coghill said.
"These kinds of structural differences can provide a foundation for the development of better tools for the diagnosis, classification, treatment and even prevention of pain," he said.
The study was published in the journal Pain.