Dog sniffs out thyroid cancer in US

US researchers have successfully used a dog to sniff out thyroid cancer in people who had not yet been diagnosed.
The trained scent dog accurately identified whether patients' urine samples had thyroid cancer or were benign (noncancerous) 88.2 per cent of the time, researchers said.
"Current diagnostic procedures for thyroid cancer often yield uncertain results, leading to recurrent medical procedures and a large number of thyroid surgeries performed unnecessarily," said the study's senior investigator, Donald Bodenner, chief of endocrine oncology at the University of Arkansas for Medical Sciences (UAMS) in US.
"Scent-trained canines could be used by physicians to detect the presence of thyroid cancer at an early stage and to avoid surgery when unwarranted," Bodenner said.

Although Bodenner is not yet basing patient treatment decisions on the canine technique, he said the dog's diagnostic accuracy is only slightly less than that of fine-needle aspiration biopsy, the method generally used first to test thyroid nodules for cancer.
Canine scent detection has the advantages of being noninvasive and inexpensive, he said.

Bodenner's colleague at UAMS and a study-coauthor, Arny Ferrando, previously "imprinted," or scent-trained, a rescued male German Shepherd-mix named Frankie to recognise the smell of cancer in thyroid tissue obtained from multiple patients.
Ferrando, who noted that dogs have at least 10 times more smell receptors than humans do, said, "Frankie is the first dog trained to differentiate benign thyroid disease from thyroid cancer by smelling a person's urine."

In this study, 34 patients gave a urine sample at their first visit to the university thyroid clinic before they went on to have a biopsy of suspicious thyroid nodules and surgery. The surgical pathology result was diagnosed as cancer in 15 patients and benign thyroid disease in 19.
These urine samples were presented, by a gloved dog handler, one at a time to Frankie to sniff.
Neither the dog handler nor the study coordinator, who recorded the dog's responses after the handler announced them, knew the cancer status of the 34 urine samples.
The handler interspersed some urine samples that had a known cancer status so he could reward the dog for correct answers: alerting to a cancer sample by lying down, and turning away from a benign sample to alert the absence of cancer.

The dog's alert matched the final surgical pathology diagnosis in 30 of the 34 study samples, the investigators said.
The sensitivity, or true-positive rate, was 86.7 per cent, meaning Frankie correctly identified nearly 87 per cent of the pathology-proven thyroid cancers.
The specificity - the true-negative rate - was 89.5 per cent, which meant Frankie knew that a benign sample was actually benign almost 9 of every 10 times.