Drugs that mimic benefits of exercise in the offing

Drugs that mimic the benefits of exercise could soon become a reality, thanks to breakthrough research which discovered around 1,000 molecular reactions to exercise.
The research exposed a thousand molecular changes that occur in our muscles when we exercise, providing the world's first comprehensive exercise blueprint.
"Exercise is the most powerful therapy for many human diseases, including type 2 diabetes, cardiovascular disease and neurological disorders," said David James, Professor at University of Sydney and the head of the research group.
"However, for many people, exercise isn't a viable treatment option. This means it is essential we find ways of developing drugs that mimic the benefits of exercise," said James.

The University of Sydney researchers, in collaboration with researchers from the University of Copenhagen in Denmark, analysed human skeletal muscle biopsies from four untrained, healthy males following 10 minutes of high intensity exercise.
Using a technique known as mass spectrometry to study a process called protein phosphorylation, co-author Dr Benjamin Parker discovered that short, intensive exercise triggers more than 1,000 changes.

Most traditional drugs target individual molecules. With this exercise blueprint we have proven that any drug that mimics exercise will need to target multiple molecules and possibly even pathways.
The majority of changes they discovered have not previously been associated with exercise, with existing research focusing on just a small number of changes.

"Exercise produces an extremely complex, cascading set of responses within human muscle. It plays an essential role in controlling energy metabolism and insulin sensitivity," said co-author Dr Nolan Hoffman from the Charles Perkins Centre and Faculty of Science.
"While scientists have long suspected that exercise causes a complicated series of changes to human muscle, this is the first time we have been able to map exactly what happens.
"This is a major breakthrough, as it allows scientists to use this information to design a drug that mimics the true beneficial changes caused by exercise," Hoffman said.
With this long-term goal in mind, researchers narrowed down the therapeutic possibilities within the blueprint using mathematical and engineering-based analysis.

"Most traditional drugs target individual molecules. With this exercise blueprint we have proven that any drug that mimics exercise will need to target multiple molecules and possibly even pathways, which are a combination of molecules working together. We believe this is the key to unlocking the riddle of drug treatments to mimic exercise," James said.
The study was published in the journal Cell Metabolism.