Ronaldo, a three-time world player of the year, has never scored a goal at the San Siro but has the chance to match and surpass his own record of scoring 17 Champions League goals in a season.
Yet two years after Real defender Sergio Ramos levelled at the death to inspire a stunning, extra-time comeback and secure a 10th triumph in Lisbon, the Portuguese superstar insists winning an 11th crown is far more important than who hits the net at the San Siro.
Victory would see Real Madrid embellish their reputation as the most successful club in Europe having won the inaugural edition, the European Champions Clubs' Cup, in 1956 when Argentinian Hector Rial struck the winner in a 4-3 victory over fallen French giants Stade Reims in Paris.
Atletico's achievements may pale in comparison, but the threat from Diego Simeone's men, who have restricted Real to only one win in their past 10 meetings since the 2014 final, is real.
Yet only two years after Lisbon, Simeone's men are back having stunned Barcelona in the quarter-finals, and ended the hopes of the Catalan giants' former coach Pep Guardiola when they ousted his Bayern Munich side on away goals in the semi-finals.
Real fans may have the history, but Zinedine Zindane's men have beaten Atletico only once in 10 meetings since their 4-1 victory in Lisbon two years ago.
Unsurprisingly, Simeone is bullish ahead of a clash that Ronaldo says will settle which side rules the roost in the Spanish capital.
a solid defence and making sure his players remain vigilant at set-pieces.
"Madrid are different to Barcelona and Bayern; they're a much more direct team who are a massive threat from set pieces.
"We'll be ready and will look to play the game on our terms. Fingers crossed, that will be enough for us to do what we want, which is to win."
Whoever wins, says Ronaldo, will earn the local bragging rights: "We will see who is the best. I am positive. I think Real are better than Atletico, but we have to show it on the pitch."
Ramos's 93rd minute leveller, however, pushed the match into extra time and, with the fresh momentum, Gareth Bale, Marcelo and Ronaldo, from the spot, struck to compound Atletico's misery.
Now, it is Ronaldo, Bale and French striker Karim Benzema who could have their work cut out, while Ramos and Pepe, Zidane's preferred centre-back partnership, will be wary of a repeat of recent history.
They also managed a 1-0 win at Real's Santiago Bernabeu to inflict Zidane's only La Liga defeat in four months in charge when the sides last met in February.
Ronaldo, who suffered an injury scare in recen days, admitted: "Atletico always play the same way. We know there will be very few opportunities because they all play behind the ball.
"It is no coincidence that Barca and Bayern couldn't score many goals against them.
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