A strike by a US Predator drone struck a vehicle in Syria's Idlib province, believed to be carrying Drugeon, the Fox News said.
The car's driver lost a leg and was not expected to live, while a passenger believed to be Drugeon was killed, Fox said, citing "well-placed military sources."
US officials confirmed to Fox they had carried out strikes Wednesday but said they were still assessing the damage and could not confirm Drugeon had been killed.
The militant group confirmed the strikes on Twitter, saying they were carried out by "the alliance of Crusaders and Arabs on Al-Nusra positions, causing deaths, mostly of civilians."
Most US air strikes in Syria have targeted the Islamic State militant group, but Washington said on the first day of bombings on September 23 they had also hit the Khorasan group of Al-Qaeda veterans. Analysts at the time said the strike actually targeted Al-Nusra.
Drugeon, who hails from Brittany in western France, reportedly joined an al-Qaeda faction in Pakistan fighting US troops in neighboring Afghanistan in 2010.
He learned to make bombs there, and, according to reports citing French intelligence sources, developed a method to escape airport security by dipping clothing in explosives.
At some point last year or early this year, Drugeon is believed to have traveled to Syria to join the Khorasan group, part of a wave of militant migration.
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