The bill would allow the government to avoid what would surely be lengthy, heated debate on a volatile subject in France.
The move is controversial and far-left lawmakers have called the debate, to last for a week, the "mother of battles."
France's jobless rate has hovered around 10 percent for years, and Macron has vowed to bring it down by the end of his five-year term.
Details of the labor reforms are to be unveiled in late August. The government proposes to cap the financial penalty for companies sued for firing employees, and to allow businesses more flexibility to define internal working rules.
Labor Minister Muriel Penicaud said at the opening of debate that the law will aim to give a larger voice to companies, simplifying negotiations and ultimately renovating employer-employee relations so that the workplace "is not a place of conflict."
"Too many laws don't protect well," she said.
"We want to create new laws so employees are better protected," said Adrien Quatennas, a far-left lawmaker whose group filed a motion to reject the bill.
Far-left leader Jean-Luc Melenchon, who won a seat in June parliamentary elections, has called for protests on Wednesday. The Communist-backed CGT union plans a protest for September.
In the end, "they're going to put texts under our noses that we can't say anything about," CGT leader Philippe Martinez said on the BFM-TV station.
However, easy sailing in parliament does not guarantee a smooth ride.
Under Macron's predecessor, Francois Hollande, attempts to ease labor rules drew tens of thousands of people onto the streets for months.
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