"There was a large explosion at dawn today in Hasakeh city caused by an Islamic State car bomb attack on a base belonging to the Kurdish internal security forces," the Syrian Observatory for Human Rights said.
The Britain-based group said IS jihadist militants opened fire on Kurdish forces after the blast, prompting fierce clashes.
All the attackers were killed, the Observatory said, without specifying the number of IS fighters involved in the assault in the provincial capital, where Kurdish and regime forces share control.
Syrian state media reported a "terrorist car bomb" in Hasakeh city had left several dead and wounded, without giving a toll, and said the jihadists had also bombarded the city.
"IS terrorists targeted neighbourhoods (of Hasakeh city) with rockets and mortars," killing three people and wounding four more, the official news agency SANA said.
The Observatory said at least four people had been killed in the bombardment.
In the southern province of Quneitra, rebel fighters led by Al-Qaeda's Syrian affiliate Al-Nusra Front chased out IS-linked Jaysh al-Jihad from areas bordering the Israeli-occupied portion of the Golan Heights.
He said the coalition of Al-Nusra, Islamist factions and local rebels had retaken control of the village of Al-Qahtaniyah and surrounding areas.
Clashes and fierce shelling in the area began on April 27, after Jaysh al-Jihad ambushed local rebels, killing six.
East of the Syrian capital, the Observatory said rebels had regained control of a town and a key road leading to the besieged anti-regime bastion of Eastern Ghouta.
"Regime forces collapsed and were forced to withdraw from the area," the Observatory said.
"We retook Maydaa on Tuesday, and on Wednesday we took control over other areas previously under the control of the army," said Islam Alloush, spokesman for Jaysh al-Islam, the largest rebel group in the area.
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