The deputy chief of the World Health Organization, Bruce Aylward, said the study from the medical journal Lancet which focused on a small sample of people in French Polynesia provided compelling evidence that Zika triggers the syndrome.
"This is the strongest evidence so far that this may be a causal relationship," Aylward told journalists, referring to Zika's link to GBS, which causes paralysis and even death in extreme cases.
Aylward added that evidence had also "continued to accumulate" in multiple studies linking Zika to microcephaly, a serious birth defect in which a baby is born with an abnormally small head and brain.
Zika, which is spreading rapidly in the Americas, is usually no more harmful than a bad cold or mild flu, but global anxiety about the mosquito-borne virus has been driven by its probable link to microcephaly and GBS.
"When we look at the evidence... It is all going in one direction," Aylward said.
Nine countries in central and South America affected by the Zika outbreak have recorded an elevated number of GBS cases, according to WHO.
Brazil, which has registered an estimated 1.5 million Zika infections in the current outbreak, has seen 641 cases of microcephaly since October.
Brazil typically reports 150 cases of microcephaly per year.
WHO will next week host a meeting in Geneva to review the findings of the latest research on Zika.
The response, he said, has been complicated by the previously sparse information about Zika and the fact that, until recently, there had been no understanding of connections between Zika, microcephaly and GBS.
Aylward also responded to comments made by Carlos Nuzman, head of the organising committee for the summer Olympics in Rio de Janeiro, who said Thursday that Zika was not a threat to the Games.
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