The US President and other top world leaders, including China's Xi Jinping and Russia's Vladimir Putin, are in Lima, Peru for an Asia-Pacific Economic Cooperation (APEC) summit whose agenda has been hijacked by the Republican billionaire's shock election win last week.
Obama will today meet leaders of the 12 countries negotiating the Trans-Pacific Partnership, or TPP, a vast US-led trade accord that Trump opposes and now faces an uncertain future.
From Obama down, officials have stressed that the election has not changed US economic and strategic interests, and that Trump may yet recalibrate his views.
But there is little chance Trump's Republican allies in Congress would ratify TPP anytime soon.
"That is a real blow to US interests, economically and strategically, in terms of our position in Asia, but I think that is the reality, that the US is not going to be participating," said Matthew Goodman, an expert on Asian economics with the Center for Strategic and International Studies.
Some allies are turning their attention to a rival Chinese-backed free-trade agreement.
Japanese leader Shinzo Abe, who took domestic political risks to back TPP, visited Trump in New York on Thursday to hear from the president-elect himself.
The real estate mogul has prompted concern in Japan and South Korea in particular by questioning decades-old mutual defense obligations that underpin their security.
"It is manifestly in the United States' interests for these alliances to endure and to be a source of confidence to our partners and for them to understand that they don't need to come out from under the US umbrella," she told AFP.
Stressing that she did not want to speculate about Trump's foreign policy, she sought to reassure key US allies in NATO and the Pacific Rim that they will not be abandoned.
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