After six months on the job to study the workings of the Vatican's curia, or bureaucracy, Francis has now put his imprint on several key positions which help administer the Roman Catholic church's worldwide flock.
His management picks will likely both please and disappoint both conservatives and liberals alike, perhaps in line with his fledgling papacy, which has often defied labels in either camp.
Piacenza had only held that post since 2010, when he was appointed by Francis' predecessor, Benedict XVI, whose retro tastes in papal vestments and preference for traditional ceremonies found a supporter in the Italian prelate.
The pope transferred Piacenza to a decidedly lower command post, that of head of the Apostolic Penitentiary, a little-known Vatican tribunal that deals with confessions of sins so grave only a pope can grant absolution, such as the case of a priest who violates confessional secrecy.
His office faces many challenges, including how to reverse a priest shortage in much of the developed world and respond to persistent calls from within the rank-and-file faithful as well as some clergy that the pope consider allowing priests to marry.
In another important decision, Francis left Archbishop Gerhard Mueller in the powerful role of prefect of the Congregation for the Doctrine of the Faith. Mueller, originally appointed by Benedict XVI, directs the Holy See's crackdown on nuns suspected of undermining Catholic teaching on the priesthood and homosexuality.
Under Mueller's tenure, critics of the Vatican's strategy have so far been frustrated in their lobbying for Vatican and other church hierarchy to be held accountable for policy that for decades left pedophile priests in their ministry, merely shuffling them from parish to parish when complaints emerged.
In another watched appointment, Monsignor Nikola Eterovic, who was the official in charge of bishop synods, the occasional gatherings that bring bishops together to discuss important policies or regional problems, was transferred to the Vatican's diplomatic corps.
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