Lowe will star along-side Ginnifer Goodwin, who plays his wife, Jackie, in the made-for-TV feature for National Geographic, with the programme airing in November this year to coincide with the 50th Anniversary of JFK's death, reported Entertainment Weekly.
Filming for the TV-movie is expected to begin this month, with production starting this week in Richmond, Virginia.
The show is expected to air on November 22 and will no doubt be one of many specials aired around the same time as America mourns the 50th Anniversary of Kennedy's death.
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