While World No.1 Saina comfortably beat 67th-ranked Cheah Lyddia Yi Yu of Malaysia, World No.4 Srikanth pipped Hans-Kristian Vittinghus of Denmark in a thrilling decider.
The women's doubles pair of Jwala Gutta and Ashwini Ponnappa, too, made a winning start at the USD 750,000 event.
Among the Indians who made a first round exit were P V Sindhu, Parupalli Kashyap and R M V Gurusaidutt, who took a game off World No.1 Chen Long.
Defending champion Saina, playing her opener late in the day, breezed past Cheah 21-12 21-10 to enter the last 16 of the competition. The second seed next plays Sun Yu of China.
Srikanth was the lone winner in the men's singles, recovering to beat Vittinghus 14-21 21-8 22-20 in a match lasting 53 minutes. He plays China's Tian Houwei tomorrow.
His compatriot Kashyap went down against sixth seed Wang Zhengming in a marathon match, losing 26-24 18-21 20-22.
Gurusaidutt raised eyebrows by taking the first game from Long before the Chinese fought back to complete a 15-21 21-9 21-17 victory.
In the women's doubles, Jwala and Ashwini dispatched the Dutch pairing of Samantha Barning and Iris Tabeling 21-13 21-13.
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