Overnight data on FII selling and fag-end profit booking before monthly derivative contracts expire tomorrow, also weighed on stocks, traders said.
Shares from metal, banking, consumer durables and realty pack were among the laggards while capital goods and pharma stocks attracted good buying support, they added.
The Sensex resumed on a positive note and firmed up to a high of 20,828.68 on strong buying aided by Asian trends.
Jignesh Chaudhary, Head of Research, Veracity Broking Services said, "Both ICICI Bank and Bharti Airtel posted positive numbers in Q3 earnings, which were below markets' projections. During the later part of the day, profit booing picked up which created some pressure."
Tata Steel, Sesa Sterlite, Hindalco and RIL also fell.
However, Maruti shares with a 7 per cent spurt led the 14 Sensex gainers that included Sun Pharma, Bhel and Hero Moto.
Foreign Institutional Investors (FII) sold shares worth Rs 1,267.35 crore yesterday as per the provisional data.
Globally, markets were stable ahead of Fed meet outcome.
"The US Fed meeting result will be available tonight. The street is factoring in (another) USD 10 billion tapering," said Milan Bavishi, Head Research, Inventure Growth and Securities. The US central bank has already trimmed it by USD 10 billion to USD 75 billion per month.
Asian markets ended higher after Turkey's central bank doubled interest rates to arrest a currency slide that roiled global markets. Key benchmark indices in Hong Kong, China, Japan and South Korea rose, while the one from Singapore fell.
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