A boat was ferrying the spacecraft to a port near Los Angeles, where NASA said the haul of 1.5 tonnes of experiment results and other materials will be removed and returned to the space agency by late tomorrow for scientists to pick apart.
Dragon also carried crew supplies, hardware and computer resources.
The investigations in the cargo could help develop more efficient solar cells and semiconductor-based electronics, as well as grow plants better suited for space and improve sustainable agriculture, according to NASA.
Dragon, which spent a month at the space station, will later travel back for processing to SpaceX's test facility in McGregor, Texas.
Astronauts at the ISS had manipulated the orbiting lab's robotic arm to detach Dragon on time, at 1357 GMT, in what NASA called a "very clean release."
The capsule splashed down five-and-a-half-hours later, at 1939 GMT, near the Mexican coast, slowed by three enormous parachutes.
The SpaceX vessel is the only spacecraft currently capable of returning from the ISS with cargo. Its last mission to the space station was in April.
The lab mice were the first live mammals to hitch a ride aboard a commercial cargo ship, and they are enclosed in a NASA-made research cage for studying the effects of weightlessness on their bodies.
The 3D printer is the first of its kind to demonstrate how the technology can be used in space, even without gravity to assist the process.
The Dragon return kicks off a week of heavy traffic to and from the orbiting science lab.
And on Wednesday, the Russian cargo ship Progress is set to take off for the ISS, replacing a sister vessel due to break away from the orbiting station and return to Earth tomorrow.
You’ve reached your limit of {{free_limit}} free articles this month.
Subscribe now for unlimited access.
Already subscribed? Log in
Subscribe to read the full story →
Smart Quarterly
₹900
3 Months
₹300/Month
Smart Essential
₹2,700
1 Year
₹225/Month
Super Saver
₹3,900
2 Years
₹162/Month
Renews automatically, cancel anytime
Here’s what’s included in our digital subscription plans
Exclusive premium stories online
Over 30 premium stories daily, handpicked by our editors


Complimentary Access to The New York Times
News, Games, Cooking, Audio, Wirecutter & The Athletic
Business Standard Epaper
Digital replica of our daily newspaper — with options to read, save, and share


Curated Newsletters
Insights on markets, finance, politics, tech, and more delivered to your inbox
Market Analysis & Investment Insights
In-depth market analysis & insights with access to The Smart Investor


Archives
Repository of articles and publications dating back to 1997
Ad-free Reading
Uninterrupted reading experience with no advertisements


Seamless Access Across All Devices
Access Business Standard across devices — mobile, tablet, or PC, via web or app
