'Spinal cord, not brain, determines left or right-handedness'

Asymmetrical genetic activity in the spinal cord that begins in the womb determines if the baby will be right or left-handed, according to a new study which shows that the brain is not responsible for a person's handedness.
To date, it had been assumed that differences in gene activity of the right and left hemisphere might be responsible for a person's handedness.
A preference for moving the left or right hand develops in the womb from the eighth week of pregnancy, according to ultrasound scans carried out in the 1980s.
From the 13th week of pregnancy, unborn children prefer to suck either their right or their left thumb.

"These results fundamentally change our understanding of the cause of hemispheric asymmetries," said researchers from Ruhr University Bochum in Germany.
Arm and hand movements are initiated through the motor cortex in the brain. It sends a corresponding signal to the spinal cord, which in turn translates the command into a motion.

The motor cortex, however, is not connected to the spinal cord from the beginning. Even before the connection forms, precursors of handedness become apparent.
This is why the researchers have assumed that the cause of right respective left preference must be rooted in the spinal cord rather than in the brain.

The researchers analysed the gene expression in the spinal cord during the eighth to twelfth week of pregnancy and detected marked right-left differences in the eighth week - in precisely those spinal cord segments that control the movements of arms and legs.
Another study had shown that unborn children carry out asymmetric hand movements just as early as that.
Researchers, moreover, traced the cause of asymmetric gene activity.
Epigenetic factors appear to be at the root of it, reflecting environmental influences. Those influences might, for example, lead to enzymes bonding methyl groups to the DNA, which in turn would affect and minimise the reading of genes.

As this occurs to a different extent in the left and the right spinal cord, there is a difference to the activity of genes on both sides.
The study was published in the journal eLife.