Soon after, the Syrian Observatory for Human Rights reported an air raid on Halqi's hometown of Jassem, in the country's south, killed 11 people including eight rebel fighters.
The attacks came as UN chief Ban Ki-moon issued a new plea to Damascus to stop blocking an international inquiry into the alleged use of chemical weapons and Republican lawmakers in the United States stepped up calls for American action on the claims.
"The terrorist explosion in Mazzeh was an attempt to target the prime minister's convoy and Dr. Wael al-Halqi was unharmed," the television reported, adding the blast had caused casualties.
The Observatory said the blast killed six people including one of Halqi's bodyguards.
"A second bodyguard and the driver are in critical condition," its director Rami Abdel Rahman told AFP, adding the convoy appeared to have been targeted by a remotely-detonated car bomb.
State television said the explosion happened near a public garden and a school in Mazzeh, a well-secured district home to embassies, government buildings, intelligence facilities and politicians.
"I heard glass shattering," he added, saying he had tried to hide for fear a second explosion would follow.
An AFP photographer at the scene said vehicles were destroyed, including a bus that was burned out. The windshields of other cars nearby were also blown out.
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