While IS had been blamed for several attacks in Turkey over the last year, the brutal gun attack on the Reina nightclub 75 minutes into 2017 was distinctive in its choice of target and by the clear claim issued by the jihadists.
"Islamic State has clearly decided to target Turkey," Sinan Ulgen, chairman of the Center for Economics and Foreign Policy and visiting scholar at Carnegie Europe, told AFP.
The attack on the Reina nightclub that killed 39 people struck a symbol of the overwhelmingly Muslim country's secular society, where the Istanbul elite like to party, dance and drink.
It took place in the district of Ortakoy, a traditionally mixed area which to this day has working churches and a synagogue.
It also came on the night of New Year - as calculated by the Gregorian Calendar - which conservative Islamic hardliners in Turkey say should not be celebrated at all.
Ozgur Unluhisarcikli, Ankara office director of the German Marshall Fund of the United States, said the attack had sought "to drive another wedge between Turks with secular and conservative lifestyles."
IS has in the past claimed individual assassinations of Syrian anti-jihadist activists in southern Turkey and there was a disputed claim over a bombing in the southeast in November.
"I think they're trying to make it look like something which is unambiguously centrally-directed, rather than that just carried out by a supporter," said Charlie Winter, senior fellow at the International Centre for the Study of Radicalisation and Political Violence at King's College, London.
The attack came with Turkey deeply entrenched in a military campaign inside Syria aimed at ousting IS, as well as Kurdish militia, from the border area that has already lasted four months.
In the early years of the Syrian civil war, Ankara's Western allies accused Turkey of turning a blind eye to or even abetting the rise of IS as a useful ally in the battle against President Bashar al-Assad.
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