Nearly half of the 400,000 people trapped in eastern Ghouta suburb, northeast of Damascus, are believed to be children, according to UNICEF.
The UN agency says Thursday a survey it conducted in the area in November found 11.9 per cent of children under age 5 are suffering from acute malnutrition, a rise from only 2.1 per cent according to a similar study in January.
UNICEF Regional Director Geert Cappelaere called for the lifting of the government-imposed siege.
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