The latest advance by the Kurdish-led Syrian Democratic Forces showed that operations were still ongoing after last week's US missile attack on a Syrian army air base at the country's centre. That attack followed a chemical attack on the northern town of Khan Sheikhoun that killed 87 people.
The US blamed the Syrian government for the attack, a charge that Syria strongly denied, saying it hit a rebel arsenal that had chemical weapons.
The SDF said on social media that its fighters marched about 3 kilometres from the eastern side of Tabqa, the location of Syria's largest dam.
Separately, the Pentagon said US military advisers helped US-trained Syrian opposition forces to repel an IS attack on the al-Tanf border crossing between Syria and Iraq over the weekend.
Air Force Col John J Thomas, spokesman for US Central Command, told reporters at the Pentagon that military advisers were present at the time of the fighting.
"Ultimately the attackers were killed, defeated or chased off," he said. He said three Syrian opposition fighters were killed.
CENTCOM military command said in a statement the IS militants attacked the checkpoint with a car bomb and 20 to 30 fighters.
Last week, SDF fighters captured the area of Safsafeh, east of Tabqa, laying siege to the town. On March 22, US aircraft ferried forces behind militant lines in the Tabqa area to spearhead a major assault near the extremists' de facto capital, Raqqa.
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