Voters began casting their ballots after polling stations opened in what could be a make or break vote for Texas Senator Ted Cruz in his bid to stop Trump.
"We have to put him away tomorrow folks," Trump told a crowd in South Bend ahead of the vote.
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Ahead of the Indiana primary elections, major news outlets and political pundits projected that the Democratic presidential nomination is likely to fall into the lap of 68-year-old Clinton, while Trump is now expected to bag the Republican nomination.
And same is the mood of the nation, CNN said in its latest opinion poll.
As per a new CNN/ORC poll, 84% of voters nationwide think 69-year-old Trump will lead the Republican ticket in November, while 85% say the same about former secretary of state Clinton.
Clinton is the choice of 51% of Democratic voters, while 49% of Republican voters say they would prefer Trump to be their nominee.
Bing, the major search engine of Microsoft, yesterday predicted that at the end of the Republican primary process in California on June 7, Trump would have 1,366 delegates, 125 more than the 1,237 needed to become the presidential nominee of his party.
Similarly, Clinton would have 2,676 delegates, nearly 300 more than the 2,383 required to become the first ever woman to be a presidential nominee of a major political party.
It would also be one of the rarest occasion that the candidates would be from the same city and having their headquarters in New York.
Addressing a massive rally in Indiana, Trump exuded confidence that he will be the Republican presidential nominee.
Trump is leading in Indiana by 15 points against his nearest rival Cruz. There are 57 delegates at stake in this winner-take all state.
Trump, as per RealClearPolitics calculations, has 996 delegates, while he himself claims to have the support of at least 1,001 delegates. Cruz has 565 delegates and Governor John Kasich from Ohio has 153 delegates.
"They're finished. They're gone. They're gone," Trump said referring to Cruz and Kasich. Even a loss in Indiana, he said, would not give them any path to nomination.
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