A comprehensive accord would also see "phased, proportionate" relief from tough sanctions that have severely constrained Iran's economy, but such relief could be swiftly reversed should the Islamic republic violate any final deal, said deputy secretary of state Anthony Blinken.
Several members of Congress and other critics have warned that the ongoing negotiations between world powers and Tehran would lead to a deal that would sunset after 10 years.
Once the deal ends, critics fear, the Islamic republic could once again freely crank up its nuclear program and develop a bomb.
"To the contrary, Iran would be prohibited from developing a nuclear weapon in perpetuity -- and we would have a much greater ability to detect any effort by Iran to do so."
He said that while some constraints would be lifted after a "significant period," others would last "indefinitely, including a stringent and intrusive monitoring and inspections regim0e" by the United Nations' International Atomic Energy Agency.
And should Iran violate the agreement and begin a rush to a bomb, a process described as "breakout," Blinken stressed the restrictions on centrifuges and uranium mills would prevent Iran from completing a nuclear bomb for at least a year.
Blinken's testimony, less than two weeks before a deadline for the outlines of a major deal, came as Iran's Foreign Minister Mohammad Javad Zarif and US Secretary of State John Kerry reported progress in their talks Thursday in Switzerland, but with much work remaining.
Blinken said Iran would be indefinitely barred under the Nuclear Non-Proliferation Treaty from developing or acquiring a nuclear weapon.
Democrats and Republicans alike scoffed at the suggestion that such NPT restrictions would hold back Iran, with committee Chairman Ed Royce warning that Iranians "have been violating those commitments for years."
The deal is due to be finalized by July.
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