Karimov, 78, hasn't been seen in public since mid-August, but his government admitted only last weekend that he was ill.
His daughter Lola said he had suffered a brain hemorrhage, and a swarm of unofficial reports have placed him close to death or even dead.
"Dear compatriots, it is with a heavy heart that we inform you that the health of our President has sharply deteriorated in the past 24 hours to reach a critical state, according to the doctors," the government's statement read.
Uzbekistan celebrated its Independence Day yesterday, and it was widely assumed that the government would not break any news until after the festivities. Today, indications mounted that the country was preparing for a funeral.
The Samarkand airport issued a notice saying it would be closed to all flights except specially approved aircraft tomorrow, according to the website of the US Federal Aviation Administration.
A top diplomat in neighboring Kyrgyzstan told The Associated Press that the Kyrgyz prime minister had been invited to Karimov's funeral and would attend, leaving today or tomorrow.
The official spoke only on condition of anonymity because he was not authorised to discuss the matter publicly.
Russian presidential spokesman Dmitry Peskov said the Kremlin had no confirmation that Karimov might be dead.
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