The talks were expected to continue into the afternoon, after a first day of meetings was described as "constructive" by Iran's atomic organisation spokesman, Behrouz Kamalvandi.
Iranian media have reported little details of the negotiations with the Vienna-based International Atomic Energy Agency (IAEA).
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But the encounter is expected to broach allegations that Iran's nuclear work prior to 2003, or possibly since, had "possible military dimensions."
The IAEA is also seeking access -- which it has been denied for years -- to the Parchin military facility where it suspects Tehran may have experimented with research related to atomic weapons development.
IAEA experts held five hours of talks yesterday with Iranian nuclear officials, led by Tehran's IAEA envoy Reza Najafi, and assessed the implementation of a roadmap deal agreed on November 11.
The deal required Tehran to take six practical steps that included visits to the unfinished site of a so-called heavy water research reactor in Arak and a uranium mine in the south.
Also required from Iran was information on future research reactors, identifying sites of new nuclear power plants, and clarification on Iranian statements regarding additional enrichment facilities and laser enrichment technology.
Western powers and Israel suspect that Iran's nuclear drive masks military objectives, a claim Tehran repeatedly denies.
The November deal, struck after two years of on-off talks, was separate from a landmark agreement reached with world powers the same month that has placed temporary curbs on Iran's nuclear activities.
Implementation of the IAEA deal began in December, when inspectors visited Arak, where the small unfinished heavy water reactor has been hit by delays.
The site is of international concern because Iran could theoretically extract weapons-grade plutonium from spent fuel if it also builds a reprocessing facility.
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