Just 28 per cent of businessmen with investments in Asia Pacific Economic Cooperation (APEC) economies said they were "very confident" revenues would increase in the next 12 months, PricewaterhouseCoopers said as it released the survey.
That was down from 46 per cent last year and the lowest business confidence score since 2012, when the survey was first carried out ahead of the annual APEC summit.
This year's study polled 800 chief executive officers, PwC said.
"After a year of historic foreign direct investments into developing Asian economies, CEOs have become hypersensitive to financial market signals."
China's gross domestic product grew 7.3 per cent last year, the slowest expansion since 1990.
In the July to September period this year, growth was 6.9 per cent, the slowest in six years, according to government data.
Chinese President Xi Jinping said this month 6.5 per cent growth this year would be enough to meet the country's 2016 to 2020 growth goals.
The APEC, which groups 21 economies including includes China, the United States and Russia, aims to foster open markets among its members.
The PwC survey showed 60 per cent of CEOs in APEC believe the bloc was on the right path towards deeper economic integration, with 24 per cent saying a Pacific free-trade area could be set up by 2020.
