The cabinet said that 82 octane petrol would sell for 3.65 pounds a litre (0.80 pounds a gallon) up from 2.35 (0.52), with the same increase for diesel, while 92 octane petrol rose from 3.5 (0.77) to 5.0 (1.1) pounds.
The government first increased fuel prices in 2014 and again in November last year after floating the pound.
The country had spent billions of dollars propping up the pound, which rose from 8.9 pounds to the dollar to 18 after its flotation.
Last year, the International Monetary Fund approved a $12 billion loan to Egypt to be disbursed over three years to help finance the reforms.
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