In the second half of the 20th century, the levels of rain recorded during the Northern Hemisphere's summer monsoon fell by as much as 10 per cent, researchers said.
Changes to global rainfall patterns can have serious consequences for human health and agriculture, they said.
Scientists found that emissions of tiny air particles from man-made sources - known as anthropogenic aerosols - were the cause.
High levels of aerosols in the atmosphere cause heat from the Sun to be reflected back into space, lowering temperatures on the Earth's surface and reducing rainfall.
Researchers at the University of Edinburgh said their work provides clear evidence of human-induced rainfall change.
Alterations to summer monsoon rainfall affect the lives of billions of people, mostly those living in India, South East Asia and parts of Africa.
The team calculated the average summer monsoon rainfall in the Northern Hemisphere between 1951 and 2005. They used computer-based climate models to quantify the impact of increasing aerosol emissions and greenhouse gases over the same period.
They also took account of natural factors such as volcanic eruptions and climate variability to gauge the impact of human activity on the amount of monsoon rainfall.
"This study shows for the first time that the drying of the monsoon over the past 50 years cannot be explained by natural climate variability and that human activity has played a significant role in altering the seasonal monsoon rainfall on which billions of people depend," lead author Dr Debbie Polson, of the University of Edinburgh's School of GeoSciences, said.
The study was published in the journal Geophysical Research Letters.
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