Tens of thousands of Floridians were hunkering down in shelters for a direct hit from the monster storm, after more than 6.3 million -- nearly a third of the state's population -- were ordered to evacuate.
For those still at home, it was already too late to escape the wrath of what could be the worst hurricane in storm-prone Florida.
"If you have been ordered to evacuate anywhere in the state, you need to leave right now. Not tonight. Not in an hour. Now. You are running out of time to make a decision," Governor Rick Scott said hours before wind gusts began to lash the island chain known as the Florida Keys.
At North Collier Regional Park, a designated shelter just outside the city of Naples, anxious evacuees prayed they and their loved ones would remain safe when the storm made landfall.
"All we wanted to make sure is to feel safe and whatever happens we just have to start I guess from the beginning," Viviana Sierra said.
MacDill Air Force Base, the military installation home to US Central Command, issued mandatory evacuation orders with the eye of the storm expected to pass over its home city of Tampa early tomorrow. The Kennedy Space Center was also closed.
After blasting through the nearby Cuban coastline, Irma weakened from a maximum-strength Category Five to a Category Three storm, though it was still packing winds of 125 miles (200 kilometer) per hour.
With near-hurricane force winds lashing the Florida Keys starting around 8:00 pm (0100 GMT), the Miami-based National Hurricane Center (NHC) warned that "Irma is forecast to restrengthen" as it approaches mainland Florida.
There was a serious threat of flooding from storm surges of up to 15 feet (4.5 meters) along Florida's west coast -- enough to cover a house.
Terrified Cubans who rode out Irma in coastal towns after the storm made landfall Friday on the Camaguey archipelago reported "deafening" winds, uprooted trees and power lines, and blown rooftops.
There were no immediate reports of casualties, but officials reported "significant damage." A total of 1.5 million people were evacuated.
In Florida, cities on both the east and west coasts of the peninsular state took on the appearance of ghost towns, as nervous residents heeded insistent evacuation orders.
The storm was expected to move along or near Florida's southwest Gulf coast by today afternoon.
And hurricane-force winds are expected to lash the peninsula as it rolls north toward Georgia.
A tornado funnel cloud has already formed off the coast of Fort Lauderdale, with the NHC warning that "a few" more were possible in south and central Florida.
On highway 75 along the western coast of Florida, a steady stream of cars pressed northward as thousands fled at the last minute from the fast-approaching killer hurricane.
Strip malls, fast food restaurants and retail giants were all closed for business.
In Key West, police opened a "shelter of last resort" for those who had ignored mandatory evacuation orders.
Scott Abraham, who lives on the fifth floor of a beachfront apartment building in Miami Beach, is planning to ignore evacuation orders and ride the storm out with his wife and two kids.
"If I lived in a house I would have left, but if it gets flooded here it's going to take a week at least to come back. I don't want that," he said.
Cuban-American Orlando Reyes, 82, was forced to leave his assisted living facility in Miami Beach.
"It is frightening," he told AFP at a shelter in Miami. "We had to leave without a cent, without taking a bath, or bringing anything."
The storm smashed through a string of Caribbean islands, beginning with tiny Barbuda on Wednesday, followed by the holiday islands of Saint Barthelemy and Saint Martin.
Also affected were the US Virgin Islands, Puerto Rico, the Dominican Republic, Haiti and the Turks and Caicos. The Bahamas were spared Irma's worst.
"Upside-down cars are in the cemeteries. Boats are sunk in the marina, shops are destroyed."
Another powerful storm, Category Four Hurricane Jose, was heading toward the same string of Caribbean islands Irma has pummelled in recent days, though it was now forecast to be weaker than initially expected.
The deteriorating weather grounded aircraft and prevented boats from bringing relief supplies to hard-hit islands.
The US military was mobilising thousands of troops and deploying several large ships to aid with evacuations and humanitarian relief, as the Air Force removed scores of planes from the southern United States.
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