"There is no political or diplomatic involvement here," Ayelet Sheked told Israel's privately run television station Channel 2.
"It is an American legal procedure: the parole commission needs to approve his release from prison after 30 years," she said.
A US-born Israeli, Pollard was arrested in 1985 and two years later was sentenced to life in prison for passing American intelligence on Arab and Pakistani weapons to the Jewish state.
"The Department of Justice has always and continues to maintain that Jonathan Pollard should serve his full sentence for the serious crimes he committed, which in this case is a 30-year sentence as mandated by statute," its spokesman Marc Raimondi said.
Israel was deeply critical of the July 14 agreement under which Iran promised major world powers to dismantle or mothball much of its nuclear industry in return for an easing and eventual lifting of international sanctions against the Islamic republic.
"The sanctions relief offered by the deal will inject hundreds of billions of dollars into Iran's coffers," Netanyahu told visiting British Foreign Secretary Philip Hammond last week.
"This money will bankroll Iran's aggression in the region and its terrorism worldwide."
Israeli lawmaker Nahman Shai, chairman of parliament's lobby for Jonathan Pollard, said he believed a decision to release him could be linked to the storm over Iran.
"The Americans are looking for ways to placate Israel, there's no doubt about that," Shai, of the opposition Zionist Union party, told public radio.
"They are aware of the anger and bitterness in Israel, both in political circles and among the general public.
"Pollard in their eyes is a kind of candy which could sweeten somewhat the bitterness over the Iran agreement.
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