Khurram Manzoor put on 47 for the first wicket with Ahmed Shehzad before he was caught behind off left-arm spinner Rangana Herath for 23 two deliveries before the break.
Pakistan went to lunch at 47-1 with Shehzad unbeaten on 21 and Azhar Ali yet to score. The tourists will look for a substantial total that will enable them to force a series-levelling win.
Earlier, Sri Lanka's last two wickets added 59 useful runs to the overnight score of 261-8 before the hosts were all out 45 minutes before lunch.
Opener Upul Tharanga top-scored for Sri Lanka with 92 on what remains a good batting pitch at the Sinhalese Sports Club.
Left-arm seamer Junaid Khan finished with five for 87, with all his five career five-wicket hauls coming against Sri Lanka.
Fellow seamer Wahab Riaz claimed three for 88.
Sri Lanka lead 1-0 in the two-match series after winning the first Test in Galle by seven wickets.
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