Regional military commander Lt Gen Rey Leonardo Guerrero said it was not immediately clear what caused the explosion at a massage section of the market, which was cordoned off by police bomb experts and investigators.
Police Chief Superintendent Manuel Gaerlan said witnesses gave contrasting accounts, with some saying that a cooking gas tank exploded while others suggested it may have been some kind of an explosive.
TV footage showed plastic chairs strewn about at the scene of the blast, where witnesses said the bodies of some of the dead lay scattered a few hours after the explosion. Ambulance vans drove to and from the area following the blast.
Police forces in the capital Manila went on full alert at midnight following the deadly blast.
Duterte, who served as a longtime mayor of Davao before assuming the presidency in June, was in the region but has not issued any statement. His spokesman, Ernesto Abella, urged the public to be vigilant.
"There is no cause for alarm, but it is wise to be cautious."
Philippine forces were on alert amid an ongoing military offensive against Abu Sayyaf extremists in southern Sulu province, which intensified last week after the militants beheaded a kidnapped young villager.
The militants threatened to launch an unspecified attack after the military said 30 of the gunmen were killed in the weeklong offensive.
Some commanders of the Abu Sayyaf, which is blacklisted by the United States and the Philippines as a terrorist organization for deadly bombings, ransom kidnappings and beheadings, have pledged allegiance to the Islamic State group.
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