The Irish Setter, Thendara Satisfaction, known as Jagger, is understood to have collapsed and died after returning home to Belgium on Friday from Birmingham.
Police in Belgium are investigating and a full toxicology report is expected next week, the BBC reported on the last day of the popular competition.
The Kennel Club, which organises Crufts, said it was unclear what had happened but would support the police in their investigation.
"We are deeply shocked and saddened to hear of Jagger's death and our heartfelt sympathies go out to his owners," a spokesperson said.
TV presenter Clare Balding tweeted: "Everyone at #Crufts2015 horrified at death of Irish Setter Jagger."
The dog came second in his class on Thursday at the four-day competition from March 5-8.
The Crufts, the world's largest dog show with pets competing in categories like agility and heelwork to music.
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