Pace bowling all-rounder Stokes took five wickets for 35 runs, including a spell of three for four in 13 balls shortly before tea, with Australia 241 for seven when bad light ended play on the second day.
That left Australia requiring 90 more runs to make their arch-rivals bat again, with England, 2-1 up in the five-match series, three wickets away from regaining the Ashes.
"We came in without Jimmy, who is a massive loss...I'm really happy with being given the extra responsibility," Stokes told reporters after Australia had avoided their first two-day defeat in a Test since 1890.
England had effectively sealed the destiny of this match on a first day where Australia, after losing the toss, collapsed to 60 all out in 111 balls -- the shortest-ever completed first innings of any Test match -- with Stuart Broad taking a remarkable eight for 15 on his Nottinghamshire home ground.
England piled up 391 for nine declared in reply, Joe Root top-scoring with 130.
But with Australia showing more fight with the bat second time around, England were starting to miss Anderson who was ruled out after suffering a side injury in their eight-wicket win the third Test at Edgbaston last week.
Looking ahead, the 24-year-old Durham rising star urged England to be ruthless in their pursuit of victory today.
"We're in an unbelievable position here. They're not quite in our grasp yet, but we hope they're very close.
"We know no game is over until the last wicket is taken, so we'll take that attitude in.
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