The Hulu show based on the best-selling novel by Margaret Atwood, is set in Gilead, a totalitarian society in what used to be part of the United States. Gilead is ruled by a fundamentalist regime that treats women as property of the state, and is faced with environmental disasters and a plummeting birth rate.
In a desperate attempt to repopulate a devastated world, the few remaining fertile women are forced into sexual servitude.
Moss dropped an f-bomb as she walked up to the stage to receive her award, and then called her mother a "f***ing bada**" at the end of her speech. "You are brave and strong and smart..."
She also thanked Hulu and MGM, in addition to Atwood, who wrote the book on which the series is based. "Margaret Atwood, oh my gosh, thank you for what you did in 1958 and thank you for what you continue to do for all of us."
While in tears, Dowd thanked author Atwood during her acceptance speech, as well as her family and representatives. But she also took a moment to thank the streaming service that released "The Handmaid's Tale": "They're very lovely, Hulu," she said.
Rising-star director Reed Morano, who helmed the first three episodes of the show, became the first woman to win the Emmy for drama series directing in 22 years.
"Lizzie is my ultimate inspiration," Morano said. "This is as much her as it is me."
The last female director to take the drama series directing Emmy was Mimi Leder in 1995 for the "ER" episode "Love's Labor Lost."
Bruce Miller of "The Handmaid's Tale" also won the award for writing for a drama series.
"This Is Us" star Sterling K Brown made history by becoming the first African-American to win the best actor in drama series at the Emmys in 19 years.
Brown plays Randall, the black adopted son of the otherwise white Pearson family, who is on a mission to find his biological father and explore his racial identity.
"I just want to say Mr Braugher, whether at Stanford University or on this Emmy stage, it is my supreme honour to follow in your steps," Brown said, before pivoting to thanking his TV family. "Milo, Mandy, Justin, Chrissy - you are the best white TV family that a brother has ever had. Better than Mr. Drummond, better then them white folks at Webster."
"I feel so lucky to have won this in the company of my fellow nominees.
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