The US wants Iran to negotiate over its "defensive weapon" and to reduce the range of its missiles, while urging Iran to talk over its regional strategy, the Iranian leader was quoted as saying by the Iranian news agency on Tuesday, Xinhua reported.
"Therefore, the talks (over these issues) are basically wrong," Khamenei said, stressing that holding "talks with Washington, particularly with the current US government, is poisonous."
Washington seeks to seal a new nuclear deal with Iran, which will further curb Iran's nuclear program, stop Iran's ballistic missile development, and halt Iran's push for influence in the region.
"None of our wise people (inside Iran) seeks talks with the US," said Khamenei.
"Iranians' ultimate option is to resist the US pressures, and in this confrontation Americans will have to retreat," he said.
The Iranian leader also ruled out the possibility of a war between Tehran and Washington, despite the rising tensions that have fuelled worries about an armed conflict between the two rivals.
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