"Four years is a lifetime in American politics," Biden told CNN in an interview.
"And I think that nominees are determined by their parties based mostly on what skill set is most needed at that time. Who knows where we're going to be two years from now when people really start looking seriously at what they are going to do," he said.
In the interview, the 74-year-old again did not rule out a bid to White House but acknowledged age could be a factor.
"Look, age could be very much an issue, and it may not be. It depends on the state of my health and the health of whomever is running," he said.
Biden also said that Democrats didn't show enough respect to working class voters in last month's presidential election.
In the past two years, President Barack Obama's administration had focused on addressing inequalities among people, but was not able to address their problems, he said.
"In the last two years there has been a shift in a focus, now that we got the car out of the ditch and on the road and running, on really focusing on the real inequities that exist and still exist for working-class, middle-class people who are left behind. What happened was, that wasn't the central part of the campaign moving forward, in my view," he said.
"As much as we come back, there's still a segment of people who had good, decent jobs five, 10, 12 years ago, and they are having trouble looking their kids in the eye and saying, honey, it's going to be OK, I feel certain about where we are now," Biden said.
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