The experiment is thought to be the first to show that two brains can be directly linked to allow one person to guess what's on another person's mind, researchers said.
"This is the most complex brain-to-brain experiment, I think, that's been done to date in humans," said lead author Andrea Stocco, an assistant professor of psychology and a researcher at University of Washington (UW)'s Institute for Learning and Brain Sciences.
The first participant, or "respondent," wears a cap connected to an electroencephalography (EEG) machine that records electrical brain activity.
The respondent is shown an object (for example, a dog) on a computer screen, and the second participant, or "inquirer," sees a list of possible objects and associated questions.
With the click of a mouse, the inquirer sends a question and the respondent answers "yes" or "no" by focusing on one of two flashing LED lights attached to the monitor, which flash at different frequencies.
But only a "yes" answer generates a response intense enough to stimulate the visual cortex and cause the inquirer to see a flash of light known as a "phosphene."
The phosphene - which might look like a blob, waves or a thin line - is created through a brief disruption in the visual field and tells the inquirer the answer is yes.
Through answers to these simple yes or no questions, the inquirer identifies the correct item.
The sessions were a random mixture of 10 real games and 10 control games that were structured the same way.
The researchers took steps to ensure participants couldn't use clues other than direct brain communication to complete the game.
Inquirers wore earplugs so they couldn't hear the different sounds produced by the varying stimulation intensities of the "yes" and "no" responses.
The research was published in the journal PLOS ONE.
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