Recent scientific studies, the EPA said, show current standards leave too much harmful smog in the air.
Exposure at those levels, and at levels below the current maximum, "can pose serious threats to public health," including causing asthma and other lung diseases and can even be linked to death from respiratory and cardiovascular causes, the agency said.
"Bringing ozone pollution standards in line with the latest science will clean up our air, improve access to crucial air quality information, and protect those most at-risk," EPA Administrator Gina McCarthy said in a statement.
It is also considering an even more stringent 60 ppm standard, depending on comments from the public during the review period.
The agency said it based the new recommendations on a review of more than 1,000 new studies published since the last update in 2008.
The stricter proposed standard could prevent the premature deaths of more than 750 and up to 4,300 people a year, the EPA said.
The agency is legally required to review its air pollution standards every five years under the 1970 Clean Air Act, through a process that includes recommendations from an independent panel of experts.
Ozone, or smog, forms at ground level when heat from the sun "cooks" emissions of chemicals like nitrogen oxides and volatile organic compounds, which can come from cars, industrial or power plants, or certain paints or fuels.
The new proposed standards drew quick criticism from several big industry groups, including the American Chemistry Council.
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