Biden also said he was hopeful diplomacy is still available.
Earlier on Tuesday, NATO Secretary-General Jens Stoltenberg said that the alliance believed Russia was still planning a big assault on Ukraine following Moscow's recognition of two separatist regions in the former Soviet republic's east.
Britain published a list of sanctions and Germany froze the Nord Stream 2 Baltic Sea gas pipeline project, which would have significantly increased the flow of Russian gas.
The Dow Jones Industrial Average fell 588.86 points, or 1.73%, to 33,490.32, the S&P 500 lost 62.35 points, or 1.43%, to 4,286.52 and the Nasdaq Composite dropped 227.33 points, or 1.68%, to 13,320.74.
The Dow and Nasdaq were down more the 2% shortly before the comments from Biden.