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Excess male hormones in women may up blindness risk

IANS  |  London 

Increased levels of hormone -- male sex hormone -- in women could cause a that can lead to blindness, finds a new study.

The study, led by the in Britain, showed that excess leads to (IIH) -- high pressure in the brain -- resulting in and in women.

The findings showed that women with IIH had raised levels of testosterones compared to those with and (PCOS).

The were also found to be increased in the brain fluid of women with IIH.

"These findings mark a key step forward. For the first time we have found a pattern of androgen dysregulation that is unique to IIH and potentially a of abnormal brain pressure in people with the condition," said Alex Sinclair, from the varsity.

"Taken together this provides the first evidence that IIH may be a manifestation of female androgen excess," Sinclair added.

Originally identified over 100 years ago, the cause of IIH has remained unknown yet, despite speculation about why more than 95 per cent of the total incidence is in women with

For the study, published in the journal JCI Insight, the team examined the levels of in blood and urine, as well as in brain fluid known as cerebrospinal fluid (CSF), in 55 women aged 18 to 45 years with IIH.

They then compared the results with the levels observed in women with of the same age and body mass index (BMI), as well as a cohort of women with (PCOS).

PCOS is known to be associated with increased levels of specific types of androgens, which can cause excess hair and irregular periods.



(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Fri, March 22 2019. 19:30 IST