Lahiri, who scored 72 in the first round, had a nightmarish second round as he missed five putts 10 feet or inside and two more between 10-15 feet.
Twice he had to take a penalty and ended the day with three birdies, four bogeys and a double to miss the cut by as much as four shots.
Among those missing the cut were Paul Casey, Marc Leishman and Tyrell Hatton, all ranked among the top 20.
Bryson DeChambeau shot a career-best 7-under 64 on Friday to take the lead into the weekend.
DeChambeau's first event as a pro was at Harbour Town Golf Links in 2016. Two years later, he posted his lowest ever on the PGA TOUR to get to 10-under 132, one ahead of red-hot Ian Poulter and Si Woo Kim.
World No. 1 Dustin Johnson shot a second straight 69 and was tied for 26th, six shots off the lead.
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