It means key players are likely to be rested and others given the opportunity to stake a claim, particularly in attack, where the third spot next to Lionel Messi and Luis Suarez is yet to be established.
Ousmane Dembele has endured a difficult debut season, plagued by problems with fitness and form, but the forward has shown signs of improvement and played in the Catalan Super Cup win over Espanyol on Wednesday.
"He tried to get involved in play and has worked on individual moves," Valverde said.
"This is useful, little by little, we hope he translates it into La Liga games."
Dembele is jostling for position with the creative Philippe Coutinho, preferred against Atletico, and Paulinho, who offers the most defensive resilience from the front.
Anything but a comfortable win at La Rosaleda Stadium would represent a major shock.
Malaga were, in fact, the last team to beat Barcelona in La Liga, with a 2-0 victory in April, but few players from that triumph are still at the club while the coach, Michel, was sacked in January. His replacement, Jose Gonzalez, has overseen six defeats in a row.
It means Atletico will hold little hope of their deficit being cut this weekend but the challenge for Diego Simeones men is to stay in touch by beating ninth-placed Celta Vigo on Sunday.
A 3-0 thrashing of Lokomotiv Moscow in the Europa League on Thursday has already recovered the winning feeling, with Atletico registering eight victories on the bounce before they were halted by Messis 25-yard free-kick.
After the win over Lokomotiv, Simeone was asked about taking charge at Paris Saint-Germain next season and he indicated his focus by replying: "Celta."
Real Madrid, meanwhile, swap Paris Saint-Germain and the Parc des Princes for Eibar and the Ipurua Municipal Stadium, the smallest stadium in La Liga with a capacity of just over 7,000.
Gareth Bale is unlikely to be among those rested, however, after the Welshman missed out on the starting line-up against PSG. Bales reaction this weekend will be significant.
Elsewhere on Saturday, Sevilla host Valencia, needing a victory to reignite their hopes of qualifying for the Champions League.
Los Rojiblancos sit fifth in the table, eight points behind Valencia, knowing anything but a win this weekend would all-but end their top-four hopes.
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)