His death was announced by his family in a statement. It did not say where he died or specify the cause.
Regis, as he was universally known, was a TV personality for nearly six decades and an ABC superstar since 1988, when his New York talk show went national.
But he also wrote five books, appeared in movies, made records as a singer, gave concerts and was a one-man industry of spinoffs, from shirts and ties to medical advice and computer games.
Near the end of his career, Forbes put his net worth at $150 million, and Guinness World Records said he was the most-watched person in TV history, with more than 17,000 hours of airtime — equivalent to two full years, night and day.