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Hyper-sensitive brain network cause chronic headaches

ANI  |  Washington D.C. [U.S.] 

A new study has found that of patients with primes for rapid and global, responses to minor changes. is a characterised by widespread musculoskeletal accompanied by memory issues, sleep, fatigue, and memory issues.

It is believed that amplifies painful sensations by affecting the way your brain processes signals. The new research states that could play a part in the of fibromyalgia.

This abnormal hyper-sensitivity of brain networks, called Explosive Synchronization (ES), can be observed in other network phenomena as well across nature. The research details only the second study about ES in the human brain.

Main researchers from the and and Technology in report evidence of ES in the brains of people with fibromyalgia, a condition characterized by widespread chronic

Richard Harris, of anesthesiology at with the and Research Center was the of the study.

He said, "For the first time, this research shows that the experienced by patients may result from hypersensitive The subjects had conditions similar to other networks that undergo explosive synchronisation".

It was found that in ES, a small stimulus can lead to a dramatic synchronised reaction in the network, as can happen with a power grid failure (that rapidly turns things off) or a (that rapidly turns things on). Until recently, this phenomenon was studied in physics rather than coming in focus in

Researchers claimed it as a promising avenue to explore in the continued quest to determine how fibromyalgia is developed in a person.

UnCheol Lee, a physicist and assistant professor of anesthesiology at Medicine, said, "As opposed to the normal process of gradually linking up different centers in the brain after a stimulus, patients have conditions that predispose them to link up in an abrupt, explosive manner". He added that these conditions were similar to other networks that undergo ES, including power grids."

The research was conducted on ten female participants with fibromyalgia. They recorded electrical activities in the brains which showed baseline EEG results indicating hyper-active and unstable brain networks, Harris added.

Notably, there was a strong correlation between the degree of ES conditions and the self-reported intensity of chronic pain reported by the patients at the time of EEG testing. Computer models were then used to monitor brain activity to compare stimulus responses of fibromyalgia patients to the normal condition. As expected, the was more sensitive to electrical stimulation than the model without ES characteristics, he noted.

"We again see the is electrically unstable and sensitive". He added that this type of modeling could help guide future treatments for fibromyalgia."

Since ES can be modeled essentially outside of the brain or in a computer, researchers could exhaustively test for influential regions that transform a into a more stable one. These regions could then be targeted in living humans using noninvasive brain modulation therapies.

The research was published in Scientific Reports.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Sat, January 13 2018. 13:39 IST
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